Bioinformatics Lead

Human Immunology Core, Perelman School of Medicine, University of Pennsylvania

Nov 2018 – Present Philadelphia, PA

Bioinformatics Software Engineer

Systems Immunology Lab, School of Biomedical Engineering, Drexel University

Sep 2014 – Nov 2018 Philadelphia, PA

Research Assistant

Applied Informatics Group, Drexel University

Mar 2011 – Aug 2014 Philadelphia, PA

Visiting Scientist

Czech Technical University

Jan 2011 – Mar 2011 Prague, Czech Republic

Student Researcher

U.S. Naval Research Laboratory

Jan 2010 – Mar 2011 Washington, DC

Research Assistant

Institute for Applied Comment and Information Networking

Apr 2009 – Mar 2010 Camden, New Jersey

Web Developer


Apr 2008 – Apr 2009 Tullytown, PA

Recent Publications

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Transcriptome and unique cytokine microenvironment of Castleman disease

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID)

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

Mining the Antibody Repertoire for Solutions to SARS-CoV-2

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

Comprehensive mapping of immune perturbations associated with severe COVID-19

Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-cell lymphoblastic lymphoma/leukemia

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

Dynamic repopulation, phenotypic evolution and clonal distribution of recipient B cells and plasma cells in graft mucosa associated with rejection after human intestinal transplantation

ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data

AIRR Community Standardized Representations for Annotated Immune Repertoires

Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data

An atlas of B-cell clonal distribution in the human body

Insight into Rhinovirus-Induced Asthma Exacerbation Using High-Throughput Immunosequencing of B-Cell Repertoires

ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data

VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements

Biopython Update 2016

Dynamic Selection of Persistence and Transport Layer Protocols in Challenged Networks

A comparison of group-based data persistence techniques in MANETs

A Gossip-based Synchronization Protocol for State Consistency in Distributed Applications

NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads

Messaging the Web: Implementing an SMS System in PHP