Aaron M. Rosenfeld

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. {Luning Prak}, David Allman, Michela Locci, Norbert Pardi

DOI

Transcriptome and unique cytokine microenvironment of Castleman disease

Anna Wing, Jason Xu, Wenzhao Meng, Aaron M. Rosenfeld, Elizabeth Y. Li, Gerald Wertheim, Michele Paessler, Adam Bagg, Dale Frank, Kai Tan, David T. Teachey, Megan S. Lim, Eline Luning Prak, David C. Fajgenbaum, Vinodh Pillai

DOI

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis

PDF DOI

Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID)

Bryanna C. Reinhardt, Omar Habib, Kit L. Shaw, Elizabeth K Garabedian, Denise Ann Carbonaro-Sarracino, Dayna Renee Terrazas, Beatriz Campo-Fernandez, Satiro De Oliveira, Theodore B Moore, Alan Ikeda, Barbara C. Engel, Gregory M Podsakoff, Roger P. Hollis, Augustine Fernandes, Connie R Jackson, Sally A. Shupien, Suparna Mishra, Alejandra Davila, Jack Mottahedeh, Andrej Vitomirov, Wenzhao Meng, Aaron M. Rosenfeld, Aoife M Roche, Pascha Hokama, Shantan Reddy, John K Everett, Xiaoyan Wang, Eline T. Luning Prak, Kenneth Cornetta, Michael Hershfield, Robert Sokolic, Suk See De Ravin, Harry L Malech, Frederic D. Bushman, Fabio Candotti, Donald B Kohn

PDF DOI

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

Rishi R. Goel, Sokratis A. Apostolidis, Mark M. Painter, Divij Mathew, Ajinkya Pattekar, Oliva Kuthuru, Sigrid Gouma, Philip Hicks, Wenzhao Meng, Aaron M. Rosenfeld, Sarah Dysinger, Kendall A. Lundgreen, Leticia Kuri-Cervantes, Sharon Adamski, Amanda Hicks, Scott Korte, Derek A. Oldridge, Amy E. Baxter, Josephine R. Giles, Madison E. Weirick, Christopher M. McAllister, Jeanette Dougherty, Sherea Long, Kurt D’Andrea, Jacob T. Hamilton, Michael R. Betts, Eline T. Luning Prak, Paul Bates, Scott E. Hensley, Allison R. Greenplate, E. John Wherry

PDF DOI

IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Mayara Garcia de Mattos Barbosa, Hui Liu, Daniel Huynh, Greg Shelley, Evan T. Keller, Brian T. Emmer, Emily J. Sherman, David Ginsburg, Andrew A. Kennedy, Andrew W. Tai, Christiane E. Wobus, Carmen Mirabelli, Thomas M. Lanigan, Milagros Samaniego, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Jeffrey L. Platt, Marilia Cascalho

PDF DOI

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

Jianing Fu, Julien Zuber, Brittany Shonts, Aleksandar Obradovic, Zicheng Wang, Kristjana Frangaj, Wenzhao Meng, Aaron M. Rosenfeld, Elizabeth E. Waffarn, Peter Liou, Sai-Ping Lau, Thomas M. Savage, Suxiao Yang, Kortney Rogers, Nichole M. Danzl, Shilpa Ravella, Prakash Satwani, Alina Iuga, Siu-Hong Ho, Adam Griesemer, Yufeng Shen, Eline T. Luning Prak, Mercedes Martinez, Tomoaki Kato, Megan Sykes

PDF DOI

TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

Alberto Sada Japp*, Wenzhao Meng*, Aaron M. Rosenfeld, Daniel J. Perry*, Puchong Thirawatananond, Rhonda L. Bacher, Chengyang Liu, Jay S. Gardner, Mark A. Atkinson, Klaus H. Kaestner, Todd M. Brusko, Ali Naji, Eline T. Luning Prak, Michael R. Betts

PDF DOI

Mining the Antibody Repertoire for Solutions to SARS-CoV-2

Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak

PDF DOI

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

John L. Johnson, Rebecca L. Rosenthal, James J. Knox, Arpita Myles, Martin S. Naradikian, Joanna Madej, Mariya Kostiv, Aaron M. Rosenfeld, Wenzhao Meng, Shannon R. Christensen, Scott E. Hensley, Jonathan Yewdell, David H. Canaday, Jinfang Zhu, Adrian B. McDermott, Yoav Dori, Max Itkin, E. John Wherry, Norbert Pardi, Drew Weissman, Ali Naji, Eline T. Luning Prak, Michael R. Betts, Michael P. Cancro

PDF DOI

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, Aaron M. Rosenfeld, Caroline A.G. Ittner, Ariel R. Weisman, Roseline S. Agyekum, Divij Mathew, Amy E. Baxter, Laura A. Vella, Oliva Kuthuru, Sokratis A. Apostolidis, Luanne Bershaw, Jeanette Dougherty, Allison R. Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E. Weirick, Claudia P. Arevalo, Marcus J. Bolton, Eileen C. Goodwin, Elizabeth M. Anderson, Scott E. Hensley, Tiffanie K. Jones, Nilam S. Mangalmurti, Eline T. Luning Prak, E. John Wherry, Nuala J. Meyer, Michael R. Betts

PDF DOI

Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-cell lymphoblastic lymphoma/leukemia

Jonathan Belman, Wenzhao Meng, Hong Yi Wang, Jie Li, Honore T Strauser, Aaron M. Rosenfeld, Qian Zhang, Eline Luning Prak, Mariusz Wasik

PDF DOI

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

Nikita Trivedi, Florian Weisel, Shuchi Smita, Stephen Joachim, Muhamuda Kader, Aditya Radhakrishnan, Chris Clouser, Aaron M. Rosenfeld, Maria Chikina, Francois Vigneault, Uri Hershberg, Nahed Ismail, Mark Jay Shlomchik

PDF DOI

Dynamic repopulation, phenotypic evolution and clonal distribution of recipient B cells and plasma cells in graft mucosa associated with rejection after human intestinal transplantation

Elizabeth Waffarn, Jianing Fu, Kristjana Frangaj, Wenzhao Meng, Aaron M. Rosenfeld, Kortney Rogers, Eline Luning Prak, Mercedes Martinez, Tomoaki Kato, Megan Sykes

PDF DOI

ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data

Aaron M. Rosenfeld, Wenzhao Meng, Eline T. Luning Prak, U. Hershberg

PDF DOI

AIRR Community Standardized Representations for Annotated Immune Repertoires

Jason A. Vander Heiden, Susanna Marquez, Nishanth Marthandan, Syed Ahmad Chan Bukhari, Christian E. Busse, Brian Corrie, Uri Hershberg, Steven H. Kleinstein, Frederick A. Matsen, Duncan K. Ralph, Aaron M. Rosenfeld, Chaim A. Schramm, Scott Christley, Uri Laserson

PDF DOI

Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

Aaron M. Rosenfeld, Wenzhao Meng, Dora Y. Chen, Bochao Zhang, Tomer Granot, Donna L. Farber, Uri Hershberg, Eline T. Luning Prak

DOI

Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life

Michelle Miron, Brahma V. Kumar, Wenzhao Meng, Tomer Granot, Dustin J. Carpenter, Takashi Senda, Dora Chen, Aaron M. Rosenfeld, Bochao Zhang, Harvey Lerner, Amy L. Friedman, Uri Hershberg, Yufeng Shen, Adeeb Rahman, Eline T. Luning Prak, Donna L. Farber

DOI

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data

Florian Rubelt, Christian E Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Bürckert, Encarnita Mariotti-Ferrandiz, Lindsay G Cowell, Corey T Watson, Nishanth Marthandan, William J Faison, Uri Hershberg, Uri Laserson, Brian D Corrie, Mark M Davis, Bjoern Peters, Marie-Paule Lefranc, Jamie K Scott, Felix Breden, The AIRR Community (including Aaron M. Rosenfeld), Eline T Luning Prak, Steven H Kleinstein

DOI

An atlas of B-cell clonal distribution in the human body

Wenzhao Meng, Bochao Zhang, Gregory W Schwartz, Aaron M. Rosenfeld, Daqiu Ren, Joseph J C Thome, Dustin J Carpenter, Nobuhide Matsuoka, Harvey Lerner, Amy L Friedman, Tomer Granot, Donna L Farber, Mark J Shlomchik, Uri Hershberg, Eline T Luning Prak

DOI

Insight into Rhinovirus-Induced Asthma Exacerbation Using High-Throughput Immunosequencing of B-Cell Repertoires

Bryan Wu Yu-Chang, Aaron M. Rosenfeld, Nadine Upton, Jaideep Dhariwal, Uri Hershberg, David Kipling, Sebastian L. Johnston, Hannah J. Gould

DOI

ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data

Aaron M. Rosenfeld, Wenzhao Meng, Eline T. Luning Prak, Uri Hershberg

DOI

VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements

Inimary T. Toby, Mikhail K. Levin, Edward A. Salinas, Scott Christley, Sanchita Bhattacharya, Felix Breden, Adam Buntzman, Brian Corrie, John Fonner, Namita T. Gupta, Uri Hershberg, Nishanth Marthandan, Aaron M. Rosenfeld, William Rounds, Florian Rubelt, Walter Scarborough, Jamie K. Scott, Mohamed Uduman, Jason A. Vander Heiden, Richard H. Scheuermann, Nancy Monson, Steven H. Kleinstein, Lindsay G. Cowell

DOI

Biopython Update 2016

Christian Brueffera, Tiago Antao, Peter Cock, Eric Talevich, Michiel de Hoon, Wibowo Arindrarto, Leighton Pritchard, Anuj Sharma, Eric Rasche, Aaron M. Rosenfeld, Connor T. Skennerton, Marco Galardini, Markus Piotrowski

Dynamic Selection of Persistence and Transport Layer Protocols in Challenged Networks

Aaron M. Rosenfeld, Robert N. Lass, William C. Regli, Joseph P. Macker

DOI

A comparison of group-based data persistence techniques in MANETs

Aaron M. Rosenfeld, Robert N. Lass, Dustin S. Ingram, William C. Regli, Joseph P. Macker

DOI

A Gossip-based Synchronization Protocol for State Consistency in Distributed Applications

Aaron M. Rosenfeld, Dara Kusic, Joseph B. Kopena, William C. Regli

NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads

Gail L. Rosen, Erin R. Reichenberger, Aaron M. Rosenfeld

Messaging the Web: Implementing an SMS System in PHP

Aaron M. Rosenfeld

Aaron Rosenfeld

Bioinformatics Lead

Perelman School of Medicine, University of Pennsylvania

Biography

Interests

Education

Experience

Bioinformatics Lead

Human Immunology Core, Perelman School of Medicine, University of Pennsylvania

Bioinformatics Software Engineer

Systems Immunology Lab, School of Biomedical Engineering, Drexel University

Research Assistant

Applied Informatics Group, Drexel University

Visiting Scientist

Czech Technical University

Student Researcher

U.S. Naval Research Laboratory

Research Assistant

Institute for Applied Comment and Information Networking

Web Developer

phillyBurbs.com

Recent Publications

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Transcriptome and unique cytokine microenvironment of Castleman disease

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID)

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

Mining the Antibody Repertoire for Solutions to SARS-CoV-2

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

Comprehensive mapping of immune perturbations associated with severe COVID-19

Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-cell lymphoblastic lymphoma/leukemia

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

Dynamic repopulation, phenotypic evolution and clonal distribution of recipient B cells and plasma cells in graft mucosa associated with rejection after human intestinal transplantation

ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data

AIRR Community Standardized Representations for Annotated Immune Repertoires

Computational Evaluation of B-Cell Clone Sizes in Bulk Populations

Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data

An atlas of B-cell clonal distribution in the human body

Insight into Rhinovirus-Induced Asthma Exacerbation Using High-Throughput Immunosequencing of B-Cell Repertoires

ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data

VDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements

Biopython Update 2016

Dynamic Selection of Persistence and Transport Layer Protocols in Challenged Networks

A comparison of group-based data persistence techniques in MANETs

A Gossip-based Synchronization Protocol for State Consistency in Distributed Applications

NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads

Messaging the Web: Implementing an SMS System in PHP